What is Podophyllotoxin ?
Podophyllotoxin (abbreviated as PPT), otherwise known as podofilox, is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species.Under the trade names Condylox, a gel, and Wartec, a solution or cream, it is used on the skin as a topical treatment of external genital warts, caused by some types of the human papillomavirus (HPV), and other warts. PPT and its synthetic derivatives display a wide selection in medical applications such as purgative, vesicant, antirheumatic, antiviral, and antitumor agents. These derivatives include etoposide and teniposide. Their anticancer activity has been heavily under study and used in various chemotherapies, including lung cancer, lymphomas, and genital tumors.Historically, podophyllin, a resin extracted from Podophyllum and Sinopodophyllum species, was also used.It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system
What is Podophyllin Resin ?
Podophyllin Resin is derived from the roots of podophyllum plant. Podophylline is applied directly to genital warts.When podophylline penetrates the wart tissue, it has a toxic effect on the nuclei of the wart cells.The nucleus is the cell's control centre. Podophylline controls cell division and multiplication (mitosis).This results in the healthy growth of tissue.Podophylline is an antimitotic and by its action on the nuclei, prevents the wart cells from dividing.This stops the cells multiplying. Over time, all the wart cells die and new healthy tissue grows in their place.
Podophyllotoxin Specification:
Podophyllotoxin , Podophyllum peltatum Extract | |
Extraction source | Podophyllum peltatum Extract |
Active ingredients | Podophyllotoxin |
Specifications | Min 98% |
Test method | HPLC |
Sieve analysis | 80 mesh |
Grade | Pharmaceutical Grade, Food Grade, Cosmetic Grade, |
Appearance | White powder |
Heavy metal | 10ppm max |
Total Plate | <1000CFU/g |
Yeast&Mold | <100CFU/g |
Salmonella | Negative |
E.coli | Negative |
Packaging | For 0.5kgs to 5kgs, Aluminum foil bags + Aseptic bag vacuum packaging For 25kgs, double-layer Aseptic bag + Paper Drums |
Shelf Life | 2 years when properly stored |
Podophyllin Resin Specification:
Podophyllin Resin ,Podophyllum peltatum Extract | |
Extraction source | Podophyllum peltatum Extract |
Active ingredients | Podophyllin Resin |
Specifications | Min 50% |
Test method | HPLC |
Sieve analysis | 80 mesh |
Grade | Pharmaceutical Grade, Food Grade, Cosmetic Grade, |
Appearance | Yellow brown |
Heavy metal | 10ppm max |
Total Plate | <1000CFU/g |
Yeast&Mold | <100CFU/g |
Salmonella | Negative |
E.coli | Negative |
Packaging | For 0.5kgs to 5kgs, Aluminum foil bags + Aseptic bag vacuum packaging For 25kgs, double-layer Aseptic bag + Paper Drums |
Shelf Life | 2 years when properly stored |
Main Function:
1) Podophyllotoxin displays a range of activities such as cathartic, purgative, antiviral, vesicant, and antihelminthic.
2) Additionally, the lignan and its derivatives are exciting leads for anti-tumor agent. For instance, podophyllotoxin is the pharmacological precursor for the important anticancer drug etoposide.
3) Podophyllotoxin is also used as a gel or solution to treat genital warts with noticeably shorter duration
Main Application:
1. Podophyllotoxin displays a range of activities such as cathartic, purgative, antiviral,vesicant, and antihelminthic.
2.Additionally, the lignan and its derivatives are exciting leads for anti-tumor agent.For instance, podophyllotoxin is the pharmacological precursor for the important anticancer drug etoposide.
3.It is also used as a gel or solution to treat genital warts with noticeably shorter duration and fewer side effects.
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