Introduction:
Metformin Hydrochloride is a hypoglycemic agent. Metformin hydrochloride extract can reduce the fasting and postprandial hyperglycemia in patients with type 2 diabetes. The HbAlc can decrease by 1% to 2%. The mechanism of reducing blood glucose in 3-(diaminomethylidene)-1 may be:
(1) increasing the sensitivity of the surrounding tissue to insulin and increasing the glucose utilization mediated by insulin.
(2) increase the utilization of glucose by non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestinal tract, skin and so on.
(3)The inhibition of hepatic gluconeogenesis, decreased glycogen output.
(4)Inhibit the uptake of glucose in the intestinal wall cells.
Specification:
Product Name | Metformin Hydrochloride Extract | |
CAS | 1115-70-4 | |
MF | 214-230-6 | |
Type | Antibiotic and Antimicrobial Agents | |
Grade Standard | Medicine Grade | |
Usage | Animal Pharmaceuticals | |
Items | Specifications | Results |
Appearance | White to whitish crystal powder | Conforms |
Residue on ignition | NMT 0.1% | Conforms |
Heavy metal | NMT 20ppm | Conforms |
Assay (HPLC) | NLT 99.5% | 99.77% |
Related substances | NMT 0.5% | 0.23% |
Single impurity | NMT 0.1% | 0.07% |
Conclusion: | Complies to the Enterprise standard |
Analysis :
Item | Specifications (USP) | Specifications (AJI) |
Description | White crystals or crystalline powder | White crystals or crystalline powder |
Identification | Infrared absorption spectrum | Infrared absorption spectrum |
Specific rotation | +26.3 °- +27.7° | +26.9 °- +27.9° |
Chloride (Cl) | ≤ 0.05% | ≤ 0.020% |
Ammonium (NH4) | --- | ≤ 0.02% |
Sulfate (SO4) | ≤ 0.03% | ≤ 0.020% |
Iron (Fe) | ≤ 0.003% | ≤ 10PPm |
Heavy metals (Pb) | ≤ 0.0015% | ≤ 10PPm |
Loss on drying | ≤ 0.5% | ≤ 0.5% |
Residue on ignition | ≤ 0.3% | ≤ 0.10% |
Assay | 98.5-101.5% | 99.0 - 101.0% |
Arsenic (As2O3) | -- | ≤ 1PPm |
The Function&Application
1.It is a drug commonleaty used to tr diabetes and cancer.
2.It is used for decreasing blood sugar levels in people with type 2 diabetes.
3.It reduces the amount of sugar made by the liver, limits the amount of sugar absorbed into the body from the diet, and makes insulin receptors more sensitive (helping the body respond better to its own insulin). The effects of metformin hydrochloride extract cause a decrease in blood sugar levels.
4.It is typically taken one to three times a day and comes in several forms and strengths. Metformin HCL comes in tablet form, two different long-acting forms, and a liquid version.
Packing&Delivery
1--Standard Package: 25KG/drum,Double Aseptic food poly bags inside,Paper Drums outside.
1--Sample Package: Aluminum foil bag.
2--Quantity Less than 50kgs, Recommend to take by DHL,UPS,TNT,EMS,Fedex.
3--Quantity Less than 200kgs, Recommend to take Air Shipment.
4--Quantity More than 200kgs, Recommend to take Sea Shipment.
5--Lead Time: By Express Courier, around 4 to 7 days.
By Air, around 2 to 4 days
By Sea, around 7 to 30days.
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