What is the synthesis process of Beta-Nicotinamide Mononucleotide (NMN)?

- Feb 02, 2021-

In China, Beta-Nicotinamide Mononucleotide (NMN) is also receiving more and more attention, the demand for its raw materials is increasing. Therefore, Rebecca Bio-Tech Co.,LTD is here to show you two synthesis processes for your reference.

One is the tribenzoyl-β-D-ribose (2) developed by Mikhailopulo et al. to prepare the target product NMN through bromination, nicotinamide substitution, debenzoyl protection, and phosphorylation. the method has shorter steps and higher total yield. However, there are problems such as unfriendly environment and expensive raw materials.

NMN Route 1

The second is an improved process based on the first one. The process uses acetyl ribose as the raw material, and also prepares the target product Beta-Nicotinamide Mononucleotide (NMN) by bromination, nicotinamide substitution, debenzoyl protection group, and phosphorylation. Compared with Route 1, the process has the characteristics of cheap and readily available raw materials, milder reaction conditions, and high atom economy.

NMN Route 2

All in all, researchers have never stopped the development of a better process for NMN. At the same time, as the research of NMN continues to deepen, its medicinal demand will continue to increase. Secondly, the health function of Beta-Nicotinamide Mononucleotide (NMN) has been successively recognized overseas, the demand for health food is also expected to achieve substantial growth. It is a drug and potential health food worthy of attention.


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