What is synephrine used for?

- Oct 12, 2020-

Synephrine belongs to the ephedrine class of alkaloids, its molecular structure contains both phenolic hydroxyl and amino groups. Therefore, it has amphoteric properties and can combine with acids and alkalis to form salts. Free chemical substance is easily soluble in organic solvents but hardly soluble in water; its acid salt and basic salt are easily soluble in water but hardly soluble in organic solvents. it has been included in the Pharmacopoeia of the Nordic countries and the German Pharmacopoeia. It is currently believed that it can be an adrenaline alpha-receptor stimulant. it has the effect of constricting blood vessels and raising blood pressure, which has a strong effect of expanding the trachea and bronchus. Intravenous injection of anesthetized cats can completely counteract bronchoconstriction caused by histamine, and has the same effect on isolated trachea of guinea pigs. Clinically, synephrine is used to treat bronchial asthma, hypotension, collapse and shock during surgery and anesthesia, and orthostatic hypotension. it is a natural stimulant in the 21st century. It has no side effects and positive reactions. It is widely used in health care industries such as medicine, food and beverages. With the prohibition of chemical synthetic drugs, the demand and value of its will double. L-synephrine exists in the dried young fruits of lime and citrus, such as citrus fruit, green peel and other plants, the content is only 0.28-2.53%. At present, commercially available L-synephrine products have low purity and many impurities, it cannot be used in high value-added fields such as medicine. Therefore, the development of high-purity L-synephrine has become the key in this field.

Synephrine

1. The effect on cardiovascular:

The intravenous injection of Citrus aurantium, Citrus aurantium extract, Citrus aurantium injection and its active ingredient synephrine hydrochloride can significantly enhance a variety of myocardial contractility and pumping function indexes in anesthetized dogs. It has strong heart and contraction of blood vessels , Increasing the total peripheral resistance, and increasing the left ventricular pressure and arterial blood pressure. Modern studies have confirmed that Citrus aurantium can increase rabbit aortic tension and contract aortic smooth muscle in a concentration-dependent manner.

effect of synephrine on cardiovascular

2. The effect on weight loss:

Synephrine hydrochloride is used as a weight loss promoter, its mechanism of action is to stimulate β-3 adrenergic receptors to cause lipid breakdown and subsequent thermogenesis. Most dietary supplements containing it also contain other different ingredients, mainly caffeine, salicylic acid and ephedrine. The combination of the above-mentioned chemical components can improve the weight loss effect. Taking rats as the research object, repeated oral administration of commercially available synephrine hydrochloride, a standardized content of lime water alcohol extract, to evaluate its food intake and cardiovascular function,

It was found that lime extract can reduce food intake and weight gain, and the ECG of the experimental group animals showed abnormalities.

Synephrine for weight loss


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