The active ingredients in Scutellaria baicalensis have a two-way regulatory effect of immunosuppression and immune enhancement, which are expected to be used in the treatment of various allergic diseases.
Baicalin has a significant inhibitory effect on mouse CD3 + T cell proliferation induced by concanavalin (ConA) or phorbol ester polyclonal stimulant (PDB) and ionomycin (Lon), it shows obvious cycle specificity , Suggesting that baicalin has the potential to develop into an immunosuppressive agent;
At the same time, baicalin also has the effect of enhancing the body's immunity. Baicalin can significantly reduce the immune liver damage caused by BCG and lipopolysaccharide (LPS) in mice. Alanine aminotransferase (ALT) and aspartate aminotransferase ( The increase of AST) reduces hepatocyte necrosis and promotes hepatocyte proliferation.
◆Anti-ischemia reperfusion injury:
The cardio-cerebrovascular protective activity of Scutellaria baicalensis is mainly manifested in the protection of myocardial ischemia-reperfusion injury, cerebral ischemia-reperfusion injury, improvement of atherosclerotic lesion progression, blood pressure lowering, anti-thrombosis and so on.
Recent studies have shown that when myocardial ischemia is re-injected, jaundice can restore the contraction ability of myocardial cells and play a protective role, intravenous jaundice may also improve the contraction ability of endotoxin shock rats by reducing oxidative stress response and inflammatory response of the heart muscle.
Modern studies have shown that components such as baicalin and baicalein have protective effects on a variety of neurons, it may become potential drugs for the treatment of neurological diseases such as Parkinson's. Baicalin can reduce the expression of Fas protein and FasL protein, it protect the neurons of newborn hypoxic-ischemic brain damage (HIBD) mice.
◆Other Scutellaria baicalensis extracts also have the effects of treating and preventing diabetes and its complications, protecting human periodontal ligament fibroblasts, anti-parasites, anti-fetus, inhibiting lipid accumulation, and anti-photoaging. Baicalin can reduce the blood glucose concentration of diabetic rats induced by streptozotocin.
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