NMN is a rising star raw material, its full name is Beta-Nicotinamide Mononucleotide (NMN) , which is the reaction product of nicotinamide phosphoribosyl transferase, it is mainly used as the key precursor of NAD+ in the body, it performs physiological functions through transformation, such as activating NAD+ substrate Dependent enzyme Sirt1 (histone deacetylase), regulate cell survival, death and maintain redox state, etc. Studies have confirmed that Beta-Nicotinamide Mononucleotide (NMN)'s levels are related to many diseases such as cardiovascular and cerebrovascular diseases, neurodegenerative diseases, diabetes, and obesity. Let us take a look.
From the perspective of medicinal effects, the proven functions of NMN include:
Relieve and improve ischemic heart and brain damage:
a. The role of stroke treatment.
Stroke is an acute cerebrovascular disease caused by blood circulation disorders in the brain. It has the characteristics of high mortality and high disability. Studies have found that NMN can activate the Nampt-NAD+ pathway, protect brain nerves, and promote blood vessel and nerve regeneration. It has a good protective effect on nerve damage caused by cerebral hemorrhage and cerebral hemorrhage transformation, so it is a potential anti-stroke drug.
b. The effect of cardiac ischemia-reperfusion therapy.
Cardiac ischemia-reperfusion is a fatal ischemic injury, which is accompanied by inevitable death of myocardial cells and severe organ dysfunction. Ischemic preconditioning (IPC) is an endogenous defense mechanism mediated by Sirt1 that can protect myocardial vitality during transient ischemia and reperfusion. Studies have shown that Beta-Nicotinamide Mononucleotide (NMN) can protect the heart by mimicking the protective effect of ischemic preconditioning (IPC).
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