Nicotinamide mononucleotide plays an important role in human cell energy production, and it is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).
The level of NAD+ is especially important in the process of energy production and damage. NAD+ full name nicotinamide adenine dinucleotide, also known as coenzyme I or noga factor, participates in thousands of redox enzyme reactions in the human body. His main functions are shown in the figure below. Here are just a few of the required contents:
Energy Production (ATP) is a tricarboxylic acid cycle coenzyme. The energy generated by mitochondria is mainly derived from this: the reactant acetyl-CoA (Acetyl-CoA) will be decomposed into the final product to produce carbon dioxide and produce H, which will be passed to coenzyme I--nicotinamide adenine dinucleotide (NAD+) and flavin adenine dinucleotide (FAD). Make it NADH + H+ and FADH
2. NADH + H+ and FADH2 carry H into the respiratory chain, which transports electrons to O2 to produce water, while coupling oxidative phosphorylation to produce ATP, providing energy. 2, DNA Repair (PARP 1) NAD + is the only substrate for DNA repair enzyme PARP, which is involved in DNA repair, help repair damaged DNA and cells, reduce the probability of cell mutation, prevent cancer;
3. Longevity Mechanisms (Sirtuins 1-7) NAD+ can activate all 7 longevity genes (Sirtuins 1-7), effectively delaying aging. Resveratrol, which has been ignited in the market, can only activate Sirtuins1, so NAD+ has a more important impact on anti-aging and longevity. .
4. Immune Cell Signalling NAD+ can attenuate the ability of macrophages or dendritic cells to activate T cells, thereby strengthening the immune system and enhancing cellular immunity.
Other functions, you can see the picture, the basic principle can be found, there are rigorous theoretical support.
With the increase of age, the level of NAD+ in the human body is gradually decreasing, which leads to the decrease of mitochondrial activity, accelerates the aging of mitochondria, cells and even the whole body, and enters a vicious circle. At this point, it needs to be supplemented from an external source.