What Do You Know About Pterostilbene

- Jun 17, 2019-

According to Wikipedia, pterostilbene  as a dimethylated quinone derivative of resveratrol belongs to the group of phytoalexins that protect plants from pathogens and infections. In January 2013, Dr. Oz highlighted the natural ingredients of pterostilbene  and C3G on the Dr Oz Show on TV, making the pterostilbene a world-renowned reputation. Many nutrition experts believe that pterostilbene is better and more effective than resveratrol in all aspects. We can explore the details step by step.

Pterostilbene source

There are two main sources of pterostilbene, one from natural sources and the other from laboratory synthesis. In theory, red sandalwood is found in many common foods and fruits such as red sandalwood, amorpha, rhubarb, peanuts, blueberries, cranberries and grapes. Blueberries are one of the most readily available sources of pterostilbene and are usually available all year round.

In order to obtain truly significant cognitive benefits from the pterostilbene, the food source of the pterostilbene is not enough. The recommended daily dose is about 300 mg. You must eat nearly 15,000 cups of blueberries (each cup of blueberries contains only 20 micrograms of red sandalwood.) Supplements are an easy way to make this compound practical.

Blueberry extract standardized to 99% pterostilbene will be very expensive, for natural pterostilbene over USD30000 / KG. Not many nutritional manufacturers use this expensive pterostilbene in their finished supplement formulations to be affordable. Therefore, the synthetic pterostilbene composition is the main trend in the market, and the price is about several hundred dollars per kilogram, which is 98% higher than the price of natural resveratrol. 

The synthetic pterostilbene is identical in nature, ie it is identical in structure and function to that found in nature. The main difference between pterostilbene or resveratrol and naturally derived red pterostilbene or resveratrol is purity. Naturally derived compounds are extracted from plants and concentrated to functional levels. Other naturally occurring and less desirable compounds are also concentrated during this process. For example, concentrated resveratrol extract also contains concentrated sputum, such as emodin, which acts as a natural laxative and can cause discomfort to sensitive individuals.

The synthesized pterostilbene has a purity of > 99%, which means that there is no undesired or unknown in the pterostilbene material.

Resveratrol VS pterostilbene

The structure of the  pterostilbene is similar to the anti-aging compound resveratrol; the pterostilbene contains two methoxy groups and one hydroxyl group, while the resveratrol contains three hydroxyl groups. You can see their molecular structure comparison below.

Comparison of structure of red pterostilbene and resveratrol.

However, Pterostilbene is more bioavailable, and preliminary research suggests that it may be more beneficial in some respects. We compare these two components in terms of absorption, bioavailability and half-life.

Pterostilbene seems to have better oral absorption and shows better metabolic stability. In other words, when you take the pterostilbene, it will enter your system and remain active for a longer period of time. A pterin having two methoxy groups and one hydroxyl group has improved lipophilicity and a higher cellular uptake potential than resveratrol having three hydroxyl groups.

Studies have shown that red pterostilbene may be more powerful than resveratrol. In fact, combining pterostilbene with resveratrol may produce effective nutrients that help support healthy cellular functions.