Silybin is the highest content component of silymarin. It has pharmacological activities such as scavenging free radicals, anti-lipid peroxidation, protecting liver cell membranes, promoting the synthesis of DNA and structural proteins of damaged liver cells, and anti-fibrosis. It is effective against acute and chronic hepatitis, Metabolic toxic liver injury and liver cirrhosis have good curative effects. They have been marketed as drugs and are recognized as therapeutic drugs for liver injury in the world.
Silymarin is a class of dihydroflavonol compounds, which has the functions of resisting liver poisoning, protecting liver cells, etc., and can be used as a bile excretion agent. It has a good effect on acute and diffuse hepatitis, liver cirrhosis, metabolic toxic liver injury, recurrent pain caused by gallstones and gallstones, and cholangitis and other hepatobiliary diseases.
Hepatoprotective and antioxidant effect:
Silymarin can protect liver cell membranes by preventing lipid peroxidation and maintain the fluidity of cell membranes. It can also inhibit the release of superoxide anions from neutrophils to reduce liver cell damage caused by inflammatory cells. Studies have also shown that silibinin can increase the expression of superoxide dismutase (SOD) in lymphocytes in mice with chronic alcoholic liver disease, thereby playing an antioxidant role. In addition, studies have also reported that silibinin can reduce the production of reactive oxygen species (ROS) and malondialdehyde (MDA).
A number of studies have confirmed that silymarin can achieve anti-fibrosis effects through anti-oxidation and direct inhibition of the activation of various cytokines on hepatic stellate cells (HSC).
Liver protection and lipid-lowering effect:
Experiments in mice confirmed that silibinin can reduce the content of triglycerides (TG) in the liver and the levels of serum TG and total cholesterol (TCh). And these animal experiments also showed that after the intervention of silibinin, the liver pathology (such as steatosis, inflammation and hepatocyte ballooning) were improved to varying degrees. Studies have also suggested that the drug can reduce the body weight of test animals.
Silybin can reduce the levels of many pro-inflammatory cytokines, such as IL-8, IL-6, MCP-1 and TNF-α, thereby exerting anti-inflammatory effects. This effect is achieved by inhibiting the activities of IKK-β and p50 and p65, thereby inhibiting the effect of NF-κB.
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