Scutellaria baicalensis extract has liver protection and anti-tumor effects

- Jul 23, 2020-

◆Protect the liver and fight against ulcers:

The active research shows that Scutellaria baicalensis has the function of protecting liver injury, treating chronic hepatitis, anti-liver fibrosis and so on, and its mechanism is closely related to its inhibition of the secretion of inflammatory media and the removal of free radicals and antioxidants. Baicalin may reduce the amount of transforming growth factor-β1 (TGF-β1), TNF-α, IL-6, and inhibit the expression of platelet-derived factor-β (PDGF-β) receptors, thereby improving carbon tetrachloride The role of liver fibrosis in rats. Baicalein may inhibit the production of cytokine NO, thereby protecting mice liver damage caused by carbon tetrachloride.

For example, baicalin capsules, which are capsule preparations prepared from baicalin extracted from scutellaria, it has significant inhibitory effects on hepatitis B surface antigen, e antigen, and core antigen, it can inhibit hepatitis B virus DNA to a certain extent Copy of; After medication, it can significantly reduce the content of alanine aminotransferase, which has a better protective effect on the liver. It is clinically used for the adjuvant treatment of acute, chronic hepatitis and persistent hepatitis.

Scutellaria baicalensis

◆Antitumor:

With the further study of Scutellaria baicalensis, it has been found that has a certain inhibitory effect on a variety of tumor cells. Baicalin, baicalein, wogonin and wogonin are the material basis of the anti-tumor effect of scutellaria, but their mechanisms are different. Baicalin can inhibit the growth of rat pancreatic islet tumor cells by inducing tumor cell apoptosis. Baicalein can arrest human umbilical vein endothelial cells in G1/S phase, inhibit neovascularization and produce anti-tumor effect; baicalein can also inhibit the migration and invasion of skin cancer A431 cells to achieve anti-tumor purpose.

Recent studies have found that wogonoside can inhibit the growth of malignant glioma by inducing tumor cell apoptosis, while wogonin can upregulate the expression of natural killer cells (NK cells) GraB, enhance the effect of NK cells on gastric cancer MKN45 cells, and inhibit the growth of human ovarian cancer cell line SKOV3 nude mice transplanted tumors by inhibiting the expression of human telomerase hTERT.

The role of total flavonoids from the stems and leaves of Scutellaria baicalensis on the metastasis and invasion of tumor cells of Walker-256 tumor line. In summary, Scutellaria baicalensis has a certain anti-tumor activity and a broad anti-tumor spectrum. It can act on multiple links of tumor cell growth and play an anti-tumor effect.


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