Resveratrol application

- Jun 25, 2019-

If you've heard that red wine can help lower cholesterol, chances are you've heard of resveratrol — the much-hyped plant compound found in red wine.

But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right. Here will I introduce the application of resveratrol.

Uses in anti-tumor field: The most striking effect of various pharmacological effects of resveratrol is anti-tumor effect. The anti-tumor effect of resveratrol is shown to inhibit the three stages of tumor initiation, promotion and development. It can exert various degrees of antagonism on various tumor cells such as human hepatocellular carcinoma, breast cancer, gastric cancer, lung cancer, rectal cancer, prostate cancer and leukemia through various mechanisms. The approximate mechanism is as follows: (1) exerts anti-initiation activity through anti-oxidation, anti-mutation, inhibition of free radicals, induction of biphasic pharmacozygous enzymes, and anti-dioxin; 2 through anti-inflammatory, inhibition of cyclooxygenase and peroxidation The activity of hydrogenase inhibits the promotion of cancer; 3 inhibits the development of cancer by inducing apoptosis of human promyelocytic leukocytes and inducing apoptosis of cancer cells.

Protection of cardiovascular function: In recent years, the protective effect of resveratrol on the cardiovascular system has attracted more and more attention from scholars.

Antioxidant: In order to better maintain the body's stability and scavenge free radicals, there is a natural antioxidant system in the human body. Numerous studies have shown that resveratrol can effectively activate the body's antioxidant enzymes or prevent it at a small concentration. It oxidizes.

Anti-inflammatory effects: In vitro experiments have shown that resveratrol can inhibit lipopolysaccharide-activated macrophage-inducible nitric oxide synthase, thereby inhibiting the production of nitric oxide, a proinflammatory factor, by down-regulating nuclear factors. Produced by the activity of κB. The main anti-inflammatory mechanism of resveratrol may be to reduce the production of cytokines, thereby inhibiting the occurrence of inflammation or reducing the degree of inflammation and shortening the duration of inflammation.

Resveratrol

Antibacterial uses: Resveratrol was first recognized as a plant antibacterial agent produced by a grape plant under adverse conditions such as fungal infection and ultraviolet radiation. The STS gene of the grape stem was isolated and transferred to tobacco. It was found that when the tobacco was infected by the pathogen, the infection site was aggregated with trans-resveratrol, and its synthesis was resistant to tobacco against B. cinerea. Ability is positively related. Studies have also shown that resveratrol also inhibits human skin fungi and skin bacteria.

Estrogen-like effects: In the study of the effects of resveratrol on estrogen-dependent human breast cancer cell lines and human ovarian cancer, it has been found to act as both an estrogen antagonist and an intrinsic estrogen-like activity, inhibiting the human mammary gland. Cancer growth. Therefore, resveratrol is added as a phytoestrogens additive to drugs or foods to prevent a series of diseases caused by insufficient female hormone secretion during menopause.

Prevention of menopausal osteoporosis: It is well known that red wine has a protective effect on cardiovascular health, and resveratrol is considered to be one of the active ingredients. Studies have shown that daily intake of 100 μg of resveratrol (about 4 cups) from wine can effectively increase the bone density of menopausal women, in addition to the substance that activates alkaline phosphatase, a key enzyme in bone mineralization. It may also be associated with inhibition of bone resorption by resveratrol with an estrogen-like effect. Of course this requires further animal experiments to confirm.