Preparation method of Ginkgo Biloba Leaf Extract

- Dec 31, 2020-

Organic solvent extraction method: it is the most widely used in production, The solvent is mainly ethanol-water solution or acetone-water solution. The crude ginkgo biloba extract is obtained by drying and crushing the ginkgo biloba leaves, soaking and extracting, filtering and distilling. On this basis, the liquid-liquid extraction, precipitation, adsorption elution and other processes can be used to obtain the refined Ginkgo Biloba Leaf Extract. The process is complicated, time-consuming, and low in yield. Residual solvents in the product will affect product quality. In recent years, resin adsorption purification methods have been increasingly used in the extraction process of Ginkgo biloba. Studies have found that the types and processes of adsorption resins used are different. Both flavonol glycosides and lactones have good yields, Each has its own character. Studies have taken the adsorption performance of Ginkgo flavonoids as an indicator and screened 10 kinds of macroporous resins and found that AB-8 resin has excellent adsorption performance, with an adsorption capacity of 102.8 mg/g and a resolution rate of 97.9%. The resin adsorption production process has the advantages of less residual organic solvents, low cost, and high recovery rate. It has a broad development prospect in the preparation and production of Ginkgo Biloba Leaf Extract and preparations.

Organic solvent extraction method

Supercritical fluid extraction method: Compared with the organic solvent extraction method, this method has the advantages of safety, non-toxicity, no solvent residue, active ingredients and volatile, less loss of heat-sensitive components, and high extraction efficiency. By adjusting the critical temperature and pressure, and changing the type and amount of modifiers, it is also possible to selectively extract, separate and purify the target. Some studies have established a set of supercritical CO2 extraction small-scale and pilot-scale equipment, and determined the optimal experimental parameters for the extraction of active ingredients from Ginkgo biloba leaves. The content of flavonoids and terpenoid lactones in the obtained Ginkgo Biloba Leaf Extracts are higher than international standards , Respectively 28% and 7.2%. At present, the application of supercritical fluid extraction technology in the extraction of active ingredients of traditional Chinese medicine is more and more extensive.

Supercritical fluid extraction method

High-speed countercurrent chromatography technology: It is a new type of chromatography technology based on the principle of liquid-liquid distribution and does not require a fixed carrier. It has a wide range of solvent systems, high separation efficiency, and large preparation volume, which is very suitable for the preparative separation of Chinese medicine extracts. At present, the technology has been applied to separate flavonoids, terpene lactones and ginkgolic acid from ginkgo biloba leaves, which will become a better method for preparing ginkgo flavonoids and terpene lactones.

Ginkgo Biloba Leaf Extract

High-speed countercurrent chromatography technology

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