Results In vitro experiment indicated that Magnolia decoction has antibacterial effect on Gram-positive bacteria such as Staphylococcus, Pneumococcus, Streptococcus hemolyticus, and Gram-negative bacteria such as Shigella, Typhoid, Escherichia coli and Bacillus subtilis. The antibacterial effect of 62 kinds of Chinese medicinal powder on Staphylococcus albicans, Bacillus subtilis, Escherichia coli and Typhoid bacillus was checked on the plate, especially Magnolia Bark extract was the strongest. Tests show that Magnolia officinalis also has a certain inhibitory effect on dermatophytes.
◆Promoting motility of the smooth muscle:
Magnolia decoction showed that it can promote motility of the smooth muscle of isolated rabbit intestines and bronchi and guinea pig bronchial smooth muscle. The decoction of Magnolia officinalis in vitro showed excitatory effect at 1:166.
The three extracts of Magnolia officinalis, lignans, magnols, honokiol and monoterpene magnols, are antagonists of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen (EBv-EA). Magnolol and its hydroxymethyl derivatives have a significant inhibitory effect on the second-stage skin tumors in mice.
When the dose of magnoline is lower than the muscle relaxant dose, it has a significant effect of lowering blood pressure, which cannot be countered by antihistamines, indicating that it is not caused by the release of histamine. The time course of blood pressure reduction for intravenous injection is about 10 to 15 minutes, and for intramuscular injection can be maintained for more than 1 hour. The water-soluble tincture of Magnolia officinalis can lower blood pressure by intravenously or intramuscularly in anesthetized cats and rabbits, and increase the heart rate.
The Magnolia Bark extract has an antibacterial test on the cariogenic pathogen-Streptococcus mutans, it is found to have a high-efficiency and rapid bactericidal effect.
Magnolia Bark extract can reduce the grip strength, it has a strong inhibitory effect on the spasm induced by drugs such as strychnine, picrotoxin and pentylenetetrazole.
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