A new study from Legan State University shows that compounds in hops can fight metabolic syndrome by altering the gut microbiome and changing the metabolism of acids produced by the liver. The findings, published in the journal Molecular Nutrition and Food Research, provide key evidence of how flavonoids, a compound that contribute to the flavor of hops, and their derivatives.
The study found that jaundice (commonly abbreviated as XN) and two hydrogened derivatives, DXN and TXN, improved cognitive and other functions in people with the syndrome.
If people suffer from at least abdominal obesity, high blood pressure, high blood sugar, low "good" cholesterol levels and high levels of triglycerides, then they are considered to have metabolic syndrome. A diet high in saturated fats and refined sugars can cause chronic low-grade inflammation, leading to the development of metabolic syndrome.The syndrome is associated with cognitive impairment and dementia ,it is a major risk factor for cardiovascular disease and type 2 diabetes.
In previous studies, tests on mouse models showed that XN, DXN, and TXN improved glucose tolerance, insulin resistance, and sensitivity to leptin. In a recent study, the authors gave only experimental animals a high-fat diet, or a high-fat diet that included XN, TXN, or DXN. The scientists then measured the effects of these compounds on bile acid secretion, tissue inflammation and the composition of the gut microbiome.
Adrian Gombart, professor of Biochemistry and Biophysics at the College, the study's correspondent author, said: "Changes in gut microbiota and bile acid metabolism seem to explain, at least to some extent, why XN and its derivatives can lead to improvements in obesity and other aspects of metabolic syndrome.But this is not necessarily causal, and we need to know what changes in the microbiota are beneficial."
The hop compounds have previously been shown to have antibacterial properties, Gombart notes, "so they may kill some harmful bugs and retain other harmful ones." Further research will attempt to determine the direct effects of these compounds on the body in addition to the gut microbiome. "
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