Exploring the mechanism of cholesterol-lowering action of Oat Beta Glucan Powder

- Mar 16, 2021-

Oat Beta Glucan Powder is a kind of non-starch polysaccharide existed in oat endosperm and aleurone cell walls. It is a water-soluble dietary fiber. The basic structure is a linear polysaccharide formed by D glucose connected with β1-4, β1-3 glycosidic bonds. The ratio of these two glycosidic bonds is approximately 7:3. Because of its viscosity, It hinders the digestion and absorption of starch, protein and other substances, so it can produce some extremely beneficial physiological functions for the human body.



Scientists have discovered that Oat Beta Glucan Powder can reduce the rate of intestinal absorption of fatty acids and reduce the body's cholesterol synthesis for years. With the maturity of oat β-glucan research, scholars have carried out a large number of experiments at the level of animal and human, confirming that oat β-glucan has specific physiology function in reducing cholesterol and low-density lipoprotein. Scientists found that Oat Beta Glucan’s effect on cholesterol is mainly to significantly reduce total cholesterol (TC) and low-density lipoprotein cholesterol (LDI-TC) in plasma. while It has no obvious effect on high-density lipoprotein (HDL) and triglyceride (TG).

Oat Beta Glucan Powder

There are currently three mechanisms of cholesterol-lowering action:

①The short-chain fatty acids produced by the Oat Beta Glucan Powder's glycolysis in the body can inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA), thereby reducing the synthesis of cholesterol;

②With high viscosity, it can wrap bile acids and get rid of the body, and promote the decomposition of cholesterol;

③It can form a high-viscosity environment in the digestive tract, which can inhibit the absorption of cholesterol in food.

Studies have shown that drinking 500ml of beverages containing 1% oat β-glucan every day can reduce total cholesterol by 4.8% and low-density cholesterol by 7.7%.

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