In recent years, a number of drugs derived from natural plants have been used to treat various types of cancer, which can represent the source of secondary metabolites and develop new chemotherapy drugs for the treatment of cancer. Chinese herbal medicine has attracted extensive attention due to its high efficiency, good drug resistance and small side effects.
The motherwort blooms in April-June, red and purple like a flower. The Compendium of Materia Medica states that it is suitable for women and for the improvement of eyesight, so it is known as beneficial to mother. A plant native to China, South Korea, Japan and Cambodia up to southern Siberia, traditionally known abroad as The Chinese motherwort, is probably the most widely used in Chinese medicine. it has been widely used in folk medicine, and widely used as a medicinal plant in history, which has anti-inflammatory, antibacterial, antioxidant, antiviral, anti-cancer and other biological activities.
Chromatography of the motherwort extract shows the presence of a variety of polyphenolic compounds, including 4-hydroxyl benzoic acid, choline acid, vanilla acid, 1, 3-dicoffee acetylene acid, alpha-dimethyl benzoic acid, etc. The study found that the extract has anti-proliferation activity on grade IV gliomas, , the pharmacological mechanism behind it may be related to polyphenolic compounds it contains, in which reactive oxygen may play a key role.The possible mechanisms of action are: cell cycle blocking mediated apoptosis, gene apoptosis mediated by mitochondrial signaling and reactive oxygen-induced apoptosis. Apoptosis may be caused by sequential communication between caspases, genes, and death receptors through endogenous and exogenous pathways.
The motherwort extract has the potential to activate glioma cells to develop apoptosis through internal and external pathways, which has certain anti-cancer potential. it may directly target the mitochondria after entering the cell by regulating the molecular expression of the cell pathway, increasing membrane permeability, increasing reactive oxygen production, and inducing apoptosis.
The dose-dependent method of motherwort extract inhibits glial cell activity, which has moderate side effects and good tolerance, may therefore it become a leading compound for the promising treatment of glioblastoma.
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