Can Magnolia Bark Extract Powder Relieve Depression?

- Mar 19, 2020-

Modern pharmacological studies have shown that Magnolia bark extract powder has the effects of antibacterial, anti-inflammatory, anti-tumor, and anti-oxidant. A total of 171 chemical components were isolated and identified from Magnolia officinalis. It mainly includes lignans, phenolic acids, flavonoids and other components.

 

Magnolia bark

Depression is a common mental illness. On July 17th, researchers at the Chinese Academy of Sciences researched traditional Chinese medicine Magnolia officinalis and found a new type of small molecule with antidepressant effect on melatonin receptors, which can be used in Development of new antidepressants.


"Science and Technology Daily" recently reported: Researchers from the Kunming Institute of Botany, Chinese Academy of Sciences have found a new type of small molecule with antidepressant effect on melatonin receptors in the Chinese medicine Magnolia officinalis, which can be used for the development of new antidepressants.

Magnolia bark extract powder

Melatonin is mainly an indole hormone produced by the pineal gland. Abnormal secretion or changes in the expression and activity of the corresponding receptors can cause a series of mental illnesses such as depression and sleep disorders. Using an in vitro screening model of melatonin receptors, the researchers found that Magnolia bark extract powder has certain agonistic effects on the receptors. In order to find highly active compounds, they modified and optimized magnolol to synthesize a series of derivatives. Through in vitro activity assays, they found that magnolol glucoside was the most potent, and that magnolol had a 2.5 to 7.5-fold increase in agonistic effects on melatonin receptors. 


At the same time, the results of in vivo drug evaluation also showed that compound 7c could exert a potential antidepressant effect by affecting neurotransmitter levels in the brain of mice.


Subsequently, in vivo metabolite research and preliminary safety evaluation were performed on compound 7c. A total of 25 metabolites were detected from mouse plasma, urine and feces. Acute toxicity experiments showed that magnolia bark extract powder has good safety and has been developed into a new type of antibody Potential application prospects of depression drugs.


This result has been published in the European Journal of Medicinal Chemistry, and has applied for "Application of magnolol-4-O-β-D-glucopyranoside in the preparation of drugs for treating central nervous system diseases" and "Honokiol Application of derivatives in the preparation of drugs for treating central nervous system diseases "two Chinese patents.


For Further Information, please contact: information@sxrebecca.com