Resveratrol is an antioxidant ingredient that is actually found in red wine, but the controversy of this ingredient is also great because it is not only versatile but also has side effects!
1. Fever and analgesic effect
Resveratrol exerts therapeutic effects in a variety of different ways, with certain antipyretic and analgesic activities. Studies in intact mice and rats have shown that resveratrol gives the gastric mucosa resistance to stress ulcers caused by suppression of gastric secretion without affecting blood pressure.
2. Anti-cancer, anti-mutation effect
In 1993, Jayafilake and other studies showed that both trans-resveratrol and cis-resveratrol have anticancer activity because they inhibit the activity of protein-tyrosine kinase. Jang and other research groups further pointed out that resveratrol has a large anti-cancer activity in the three stages of cancer initiation, promotion and development, and it inhibits and even reverses the three stages of cancer. : First, the inhibition of the initial role. Reduce the formation of free radicals, induce the increase of phase II drug enzymes, antagonize the role of dioxin; Second, inhibit the promotion. Inhibition of cyclooxygenase COX, inhibition of catalase; three inhibition development. Inhibition of cancer cell proliferation, induction of cancer cell differentiation, and induction of cancer cell apoptosis. Resveratrol is expected to be an inhibitor of tyrosine protein kinase PTK. Many medical studies have found that resveratrol has many malignant tumor cells such as breast cancer, gastric cancer, colon cancer, prostate cancer, leukemia, ovarian cancer and skin cancer. Both have significant inhibitory effects.
3. Cardiovascular protection
In the folk, the traditional Chinese medicine Polygonum cuspidatum rich in resveratrol has been used to treat and prevent hyperlipidemia and arteriosclerosis. Studies have shown that resveratrol mainly exerts anti-atherosclerosis and prevention and treatment of coronary heart disease to protect the cardiovascular from the following aspects: 1. Regulate blood lipids; 2. Inhibit platelet aggregation, promote fibrinolysis, and resist thrombosis Forming action; 3. Protecting vascular endothelium and inhibiting proliferation of endothelial cells; 4. Protecting vascular smoothing cells and inhibiting their proliferation; 5. Anti-leukocyte action; 6. Antagonizing endothelin-1 (endothelin-1, ET-1 effect; Anti-low-density lipoprotein oxidation function. In experiments with endotoxin or thrombin-induced platelet activation, it was found that after pre-incubation of platelets washed with resveratrol, lipopolysaccharide alone or lipid in physiological plasma concentration The adhesion of polysaccharides and thrombin-activated platelets to collagen is blocked. Platelet adhesion to fibrinogen pretreated with resveratrol is also blocked. Resveratrol and its derivatives are more studied in recent years. The anti-toxin of phytoalexins has gradually become a research hotspot, and it is expected to make a difference in drug development for the prevention and treatment of cardiovascular diseases, but Mechanism of action is far from clear, pending further study.
4. Prevention of heart and liver damage
Resveratrol inhibits the deposition of triglycerides and cholesterol in the liver of mice. It also promotes aspartate aminotransferase and alanine aminotransferase levels by inhibiting the liver fat peroxidation reaction in mice. By analyzing these two enzymes in serum, it is possible to obtain good diagnostic information for the heart and liver.
5. Antithrombotic function
Resveratrol inhibits lipoxygenase synthesis, which is present in leukocytes, heart, brain, lungs, and spleen. Therefore, resveratrol prevents the formation of blood clots in blood vessels. It also inhibits platelet aggregation after treatment with anti-hypertensive drugs such as clonidine.